منابع مشابه
Circular RNAs in Eukaryotic Cells.
Circular RNAs (circRNAs) are now recognized as large species of transcripts in eukaryotic cells. From model organisms such as C. elegans, Drosophila, mice to human beings, thousands of circRNAs formed from back-splicing of exons have been identified. The known complexity of transcriptome has been greatly expanded upon the discovery of these RNAs. Studies about the biogenesis and physiological f...
متن کاملBiogenesis of Circular RNAs
Circular RNAs are generated during splicing through various mechanisms. Ashwal-Fluss et al. demonstrate that exon circularization and linear splicing compete with each other in a tissue-specific fashion, and Zhang et al. show that exon circularization depends on flanking intronic complementary sequences. Both papers show that several types of circular RNA transcripts can be produced from a sing...
متن کاملCircular RNAs: splicing's enigma variations.
Circular (circ)RNAs are to transcriptomics what the famous hidden musical theme is to Elgar’s Enigma Variations: woven into the entire composition but not unambiguously identified or understood by scholars to this day. Now, two studies (Hansen et al, 2013; Memczak et al, 2013) have made substantial progress in both, identifying thousands of circRNAs and beginning to crack the enigma of their ce...
متن کاملEmerging Functions of Circular RNAs
Many thousands of Circular RNAs (circRNAs) have recently been identified in metazoan genomes by transcriptome-wide sequencing. Most circRNAs are generated by back-splicing events from exons of protein-coding genes. A great deal of progress has recently been made in understanding the genome-wide expression patterns, biogenesis, and regulation of circRNAs. To date, however, few functions of circR...
متن کاملCircular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia
In acute myeloid leukemia, there is growing evidence for splicing pattern deregulation, including differential expression of linear splice isoforms of the commonly mutated gene nucleophosmin (NPM1). In this study, we detect circular RNAs of NPM1 and quantify circRNA hsa_circ_0075001 in a cohort of NPM1 wild-type and mutated acute myeloid leukemia (n=46). Hsa_circ_0075001 expression correlates p...
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ژورنال
عنوان ژورنال: Aging
سال: 2019
ISSN: 1945-4589
DOI: 10.18632/aging.102091